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Symptoms associated with vitamin B12 may mask signs of polycythemia vera

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15 Radiographs may be helpful in confirming the diagnosis

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

Semaglutide Semaglutides mechanism of action is very different but still impactful