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These alterations include biochemical defects, such as impaired control of glutamate metabolism (the major neurotransmitter) [304], as well as the loss of synaptic activity and dendrites [305], apoptosis of neurons primarily in the ganglion cell and inner nuclear layers [306,307], and the activation of microglial cells that may protect the inner retina from injury and contribute to the inflammatory response [308]

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The Inevitable: Aging and Glutathione Decline Beyond environmental and lifestyle factors, the natural process of aging also contributes to declining glutathione levels