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Collectively, these results demonstrate that USP2 deletion, either globally or specifically in TECs, protects against UUO-induced renal fibrosis and ferroptosis, likely through regulating the ubiquitination of TFRC and TXNDC5, and possibly via its own lactylation

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Notably, composite dietary fiber preserved skeletal muscle mass and function and downregulated the expression of key proteolytic markers Atrogin-1 and MuRF-1