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6,14 Furthermore, GLP-1 signaling indirectly enhances and restores the insulin signaling pathway in neurons, leading to a reduction in the phosphorylation of insulin receptor substrates and the burden caused by monomeric -synuclein

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Currently, retatrutide is being assessed as treatment for obesity in a programme of phase 3 trials (TRIUMPH) and TRIUMPH-2 (NCT05929079) aims to assess the efficacy and safety of retatrutide in people with overweight/obesity and T2D

Variations in the literature report that ACTH concentrations may or may not be affected