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As the pluripotency genes, such as Nanog , also show fluctuating expression in ESCs (Chambers et al., 2007), could this imply that the transcription of the Sox2 gene also fluctuates and causes oscillatory expression of developmental TFs without leading to differentiation

By this, we assigned a large number of high-confidence hits with log 2 enrichment factors between 1 and 5 (represented by filled squares), applied a Gene Ontology (GO) term analysis and colored hits accordingly (Fig

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