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Its pathogenesis primarily involves immune dysregulation, including breakdown of immune tolerance, alterations in the immune microenvironment, and dysregulation of T cell subsets (158, 159)

Further, ebselen follows the analogous catalytic steps as that of native GPx enzymes, and the activation energies for the ebselen-catalyzed and native enzyme-catalyzed GPx reactions are 55 kJ/mol and 36.5 kJ/mol, respectively [78]