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The changes induce the production of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-) and interleukins (IL-6 and IL-1), known as metabolic inflammation, which plays a significant part in insulin-resistant and type-2-diabetes mellitus subsequently

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But as of right now, no research has demonstrated that it suppresses tyrosinase, an enzyme required for the synthesis of melanin

Current thoughts on the use of metformin for longevity [1:21:00]