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Mitochondria process most of the cellular oxygen to provide energy that drives almost all metabolic processes, and also are the site of significant free radical production

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This review of the evidence indicating whether UA may have a protective role in the development and/or progression of PD draws on the findings of reduced serum UA in PD, critically assesses the more equivocal genetic results, and discusses experimental observations that UA may provide protection against the pathogenic mechanisms of PD

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