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Mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems

The temperature of the Europan ocean is predicted to range from 0 C to 4 C, with possibly hotspots of higher temperatures (e.g., 40 to 400 C) near regions of putative ocean floor hydrothermal activity (McCollom, 1999

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