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GENERAL DIAGNOSTIC TESTS Obtain a chest radiograph and ECG when pulmonary and cardiovascular manifestations occur days or weeks after drug therapy was started
Here, we focused primarily on the acute mitochondrial impact of 5FU, and although we arrived at the combination of 5FU and mitochondrial inhibitors (more specifically, 5FU and metformin) somewhat serendipitously, we have now generated evidence to support the use of 5FU and metformin combinations not only in patients with resistant or relapsed disease as previously suggested by others, but also in treatment-naive, first-line chemotherapy settings
While its best-known role is in erythropoiesis (red blood cell formation), its also involved in: DNA synthesis Regeneration of bone marrow, GI lining, and respiratory tract lining Nervous system development and maintenance (11) Prevention of anemia Although a B12 deficiency isnt as common as vitamin D or even folate, it still happens
The starting dose is typically 20 units (2mg)