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Further studies in Per2Luc knock-in mice revealed that chronic light-dark disruption elevated pro-inflammatory cytokines (e.g., IL1, IL6, GM-CSF) and impaired host resilience to endotoxin challenge 126

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The latter is consistent with the pseudotime analysis of our scRNA-seq data, showing that Vegfc expression is initiated in Esm1 + ECs during early steps of arterial specification and prior to Bmx expression (Supplementary Fig

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