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Smoking can reduce how well chemotherapy and radiation therapy work in the body

Tumors with alterations involving EGFR, ALK, ROS1, RET, MET, BRAF, KRAS, NTRK, or HER2 may respond to specific targeted treatments

However, the impact is asymmetrical: the tendency for adolescents to follow their friends into smoking is stronger. Haas, who worked with David Schaefer, associate professor of human evolution and social change, Arizona State University, said that the addictive effect of nicotine may be the strongest influence on an adolescents inability to help their friends quit smoking

Reducing Adolescent Risk: Toward an Integrated Approach (SAGE Publications, Inc., 2003)

Further, while there is significant overlap in gene expression changes after electronic cigarette or tobacco cigarette use, there are several genes that are distinctly altered by electronic cigarette vapor and therefore may pose distinct health risks (82)