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However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia

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2) Joint Pain and Cartilage Damage: Arthritis (Osteoarthritis and Rheumatoid Arthritis): While direct human studies on arthritis are limited, BPC-157s ability to promote collagen production and reduce inflammation suggests potential benefits for managing arthritis symptoms (8, 9)