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Patients with gastrointestinal disorders, such as Crohns disease, celiac disease, or those who have undergone gastrointestinal surgeries like bariatric surgery, may also find B12 injections advantageous

Dose adjustments can be made after 4-6 weeks based on rate of progress and tolerance

The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]

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AOD 9604 may have additional benefits beyond weight loss, including potential improvements in musculoskeletal health, joint pain relief, and more