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The research program demonstrated important safety characteristics of growth hormone fragments while highlighting the challenges of translating preclinical metabolic effects to human therapeutic applications

While topical application has minimal systemic absorption, the precautionary principle suggests avoiding use during pregnancy unless a healthcare provider approves

Consistent with this, patients with T2D responded to IGF-1 treatment with improved glucose tolerance, hyperinsulinaemia, and hyperlipidaemia as previously stated [280]

As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

ISBN 978-94-007-7499-5