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Notably, administration of Fer-1 or overexpression of SIRT7 effectively alleviated Ang II-induced epithelial-mesenchymal transition (EMT) and renal ferroptosis in hypertensive mice by suppressing the KIM-1/NOX4 signaling pathway and activating the KLF15/NRF2 and xCT/GPX4 signaling pathways, respectively [263]

104 Under these conditions, lower ROS levels always along with alleviated mtDNA damage

Therapeutic potential of chlorotoxin-like neurotoxin from the Chinese scorpion for human gliomas

Evolutionary analysis of protein and gene structures