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We demonstrated therapeutic protection of photoreceptor structure and function in a chemically-induced rat model of RP (48% increase in photopic b-wave amplitude), as well as some limited protection in an aggressive genetic mouse model ( rd10 ) of retinal degeneration (~ 31% increase in photopic b-wave amplitude) with once daily application

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These adipocyte mast cells then release pro-inflammatory cytokines, including TNF-alpha, and increase inflammation even more