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A broader range of doses and the administration frequency should be assessed in both the preclinical and clinical studies of 7nAChR ligands

Discussion Our understanding of the roles of H 2 S, RSS and RS(S) n S in biology has been constrained by the difficulty of quantifying these species 22,24,25,26,27,28,29

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In both studies, EGRIFTA-treated patients completing the 26-week treatment period were re-randomized to blinded therapy with either daily placebo or a 2 mg dose of EGRIFTA (1 mg/vial formulation) for an additional 26-week treatment period (Extension Phase) in order to assess maintenance of VAT reduction and to gather long-term safety data