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This article serves to review the normal intestinal barrier, measurement of barrier permeability, pathogenesis and main causes of altered permeability, and highlight potential alternative therapies of leaky gut in horses while relating what has been studied in other species

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Apart from these, other factors are also implicated such as phototoxic drugs, anticonvulsant medications, and certain cosmetics.[] Melasma is resistant to treatment and has a high rate of recurrence