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Carcinogenesis 31:18331843 Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T (2017) Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

It plays a vital role in energy metabolism, transporting fatty acids into mitochondria, yes, the powerhouses of your cells, where theyre converted into usable energy

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doi:10.1002/bmc.540 217