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doi: 10.1016/j.atherosclerosissup.2006.04.007 170
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Fluoxetine affects embryonic morphogenesis by inhibiting the activity of the Wnt signaling pathway and reducing cell proliferation, and activation of the Wnt signaling pathway partially mitigates the adverse effects of fluoxetine on embryonic morphology through a mechanism of action that is not directly related to the inhibition of serotonin reuptake in the synapse
Methods: COSMOS is a 7-point scale ranging from 0 (No symptoms) to 6 (Loss of independence for an instrumental/basic activity of daily living [ADL], or worse), that accounts for performance limitations and losses of hobbies or passions and of employment, educational, service, or caregiving pursuits, besides just ADLs
