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doi: 10.1016/j.ejogrb.2013.01.021 141 JamilianMMansurySBahmaniFHeidarZAmiraniEAsemiZ

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every 2 weeks (which some patients prefer) Infliximab the first anti-TNF- drug that became available a chimeric monoclonal antibody containing 25% mouse, 75% human I g G 1 that binds to soluble & membrane bound TNF- generally it is not given as monotherapy because patients can develop a tolerance or decline in efficacy due to the development of inactivating anti-chimeric antibodies (HACA) when infliximab is given without other immunosuppressant drugs

Some protocols split the daily dose into two administrations (morning and evening) to maintain more consistent plasma levels, though definitive human PK data remain sparse as of 2026

The GSH/GSSG ratio, which is usually adopted to indicate oxidative stress and damage in toxicological research, was calculated