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Prodrugs are conjugated to RNA nanoparticles via efficient click chemistry, creating an ester linker that is cleaved by esterases in tumor tissues or cells, allowing the prodrugs to return back to their original structures and chemistry upon delivery and release, minimizing toxicity

These are transferred from one substance to another

Under stimulation by lipopolysaccharide (LPS) and interferon- (IFN-), macrophages adopt the M1 phenotype ( 3 Macrophage metabolic states and tumor function Macrophage polarization is tightly governed by distinct metabolic programs that determine their effector functions within the tumor microenvironment ( 3.1 Oncogenic functions of tumor-associated macrophages Tumor-associated macrophages (TAMs) represent macrophages recruited and reprogrammed by the tumor microenvironment (TME), exhibiting distinct functional differences from conventional immune macrophages

This paradox makes biological sense when you consider the collateral vessel activation mechanism

Graphical Abstract Similar content being viewed by others Introduction The importance of sexual life to human health and the overall well-being of society has been increasingly recognized