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A network meta-analysis published in the Journal of the Endocrine Society found retatrutide achieved 23.77% weight reduction compared to 16.79% for tirzepatide when standardized across trials, with absolute weight loss of 16.34 kg versus 11.82 kg

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Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden