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Leptin may contribute to the inverse relationship between cigarette smoking and body weight, also it may contribute to increase hunger following smoking abstinence.17 Leptin serum leves are higher in LCD like NAFLD and cholelithiasis also there have been reported different mechanisms of liver damage exerted by leptin like the induction to fibrosis associated to NAFLD.18 Although current smoking is related to a lower body mass index (BMI), it is not necessarily associated with a smaller waist circumference.19 In fact, some evidence suggests that smoking is related to visceral fat accumulation.20 Smoking cessation is associated with a substantial increase in waist circumference.21 How this affects mortality risk and whether this is independent of total adiposity is unknown