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A 2019 proof-of-concept study in Human Reproduction (Romero-Ruiz et al.) provided the earlier human data: kisspeptin treatment induced gonadotropic responses and rescued ovulation in a subset of women with PMOS, demonstrating direct clinical translation from the animal work

Vacuolation is the process of forming vacuoles on a host cell

Neutrophils contribute to RA in various ways: (I) they possess a pool of highly toxic proteases that are released at sites of inflammation (II) activated neutrophils can secrete a variety of pro-inflammatory cytokines and chemokines, causing subsequent inflammation (III) activated neutrophils form neutrophil extracellular traps, which contain externalized citrulline proteins as a source of modified autoantigens for the production of ACPAs [7]

The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation resolution and myeloperoxidase in chronic kidney disease

In a multiple dosing regimen, dosage forms A and C would yield the same average blood level concentrations, although dosage form A would show somewhat greater maximum and lower minimum concentrations