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Nutrients 16 (11), 1650
Thus, after peripheral nerve injury, many pathological changes occur, including the degeneration of nerve cells and axons and the dedifferentiation of Schwann cells, the release of inflammatory and cytotoxic mediators, the infiltration and activation of immune cells in the inflamed area, as well as microglia- and astrocyte-mediated neuroinflammatory processes at the peripheral and central nervous system levels [45,46,47,48,49,50,57]
We've seen it happen, and it's frustrating