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Elucidating the A42 anti-aggregation mechanism of action of Tramiprosate in Alzheimer's disease: integrating molecular analytical methods, pharmacokinetic and clinical data

90 The dose used in this study was 2400 mg per day for 8 weeks, with significant improvements noted from week 3

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Intriguingly, ferroptosis inducers activate non-canonical endoplasmic reticulum (ER) stress cascades, including the ATF4-CHOP/ERK-eIF2 axis, while bypassing apoptosis, a resilience mechanism attenuated in LNCaP-AI cells with elevated ATF6 expression

doi: 10.1016/j.bbrc.2007.02.057