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If you feel overly jittery, anxious, or on edge this is a sign the dose may be too strong and can be lowered for comfort

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Transepithelial transport can occur by energy-independent direct uptake or paracellular diffusion, and by energy-dependent endocytic pathways and transcytosis, receptor-aided transport, or carrier-medicated translocation (Kristensen and Nielsen, 2016)

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Source: Patani, Anil et al