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Contributory factors include malnutrition [9], pregnancy [9], liver disease [10], female gender [11], and alcohol abuse [12]

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

In the liver, glutathione S-transferase enzymes conjugate GSH to reactive metabolites and toxins, making them water-soluble for excretion a process central to Phase II detoxification

The analysis should be thoroughly documented and discussed with patients as part of the informed consent process

This indicates that viral infection of a particular cell might have pleiotropic effects on non-infected bystander cells, making them more permissive to viral replication