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The in vitro studies of these covalent inhibitors showed a prolonged inactivation of the GSTP1-1 in human non-small-cell lung adenocarcinoma cells, which served as lead compounds for the further development of potent inhibitors of GSTP1-1 in cancer

This sequence merges a segment of adrenocorticotropic hormone (ACTH, specifically ACTH 4-7, or Met-Glu-His-Phe) with a Pro-Gly-Pro extension at the C-terminus

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Antibiotics 10 , 231 (2021)

Direct injection onto the lyophilised powder at high velocity creates localised turbulence that disrupts hydrogen bonds holding the protein in its biologically active conformation