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The effect of HDACi treatment was solely examined upon monotherapy with either VPA [61] or TAC [58], resulting in a statistically significant ~2-fold increased SSTR2 protein expression level after TAC treatment, while no significant changes in mRNA expression were observed after VPA treatment

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"Patients taking oral tranexamic acid [for other ailments] started reporting to their doctors that their melasma started improving while taking the drug

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doi: 10.1111/j.1464-410X.2005.05579.x 51 ChmielJAStuivenbergGAAlKFAkourisPPRazviHBurtonJPet al