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Through a review of their premarket tobacco product application, the FDA determined that these low nicotine cigarettes (0.2-0.7 mg of nicotine per cigarette, compared to an average 10-14 mg per cigarette in standard combustible cigarettes) are appropriate for the protection of the public health due to the potential for these products to reduce adult smokers nicotine dependence

In women smokers, a study found a significant difference in stiffness after smoking just one tobacco cigarette, but not after use of e-cigarettes (reviewed in [20])

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But the agency has made little progress in outlining how or when it would begin imposing nicotine restrictions