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For retatrutide , phase 2 data published in the New England Journal of Medicine (2023) demonstrated substantial mean weight reductions over 48 weeks in adults with obesity among the highest figures reported for any pharmacological agent to date

The best characterized TFs that have defined functions in regulating adult neurogenesis include: SRY-related high-mobility-group box 2 (Sox2), paired box gene 6 (Pax6), T-box brain gene 2 (Tbr2), RE1 silencing transcription factor (REST), achate-schute complex homolog-like 1 (Ascl1), the orphan nuclear hormone receptor tailless (TLX), cyclic AMP response element-binding protein (CREB), and neurogenic differentiation 1 (NeuroD1) [62,63,64,65,66,67,68,69]

Persistent activation of microglia can sustain a cycle of inflammation and oxidative stress, amplify neuronal vulnerability and accelerate neurodegeneration in PD [5]

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