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As a result of mitochondrial membrane disruption, proapoptotic factors, such as cytochrome C, are released, leading to the caspase-3 activation and apoptosis induction 114

Intracellular iron is stored in two major formsan unstable intracellular free ferrous iron pool and an inert form bound to ferritin (Fuhrmann and Brne, 2022)

In transfected human cells, the results were exactly what one would expect from knockdown of GPX1: increased oxidative stress via production of reactive oxygen species and activation of transcription factor NF-B (16)

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Liver pathologies can also limit the storage of vitamin B12 in the blood and cause a deficiency