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The peptide also strengthens the gut-brain axis

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The oral capsule format is of particular interest in this area, since the swallowed peptide is delivered directly into the gastrointestinal tract, where much of this research activity has historically been localised and where the compounds reported stability in gastric conditions is most relevant

372,373 Moreover, the -face of Cu I -coordinated His ligand interacts with residues in the second coordination shell including nearly invariant Tyr and Glu residues that are energetically linked to Cu I -mediated allosteric inhibition of DNA binding, suggesting a path for allosteric connectivity

It is a comparatively recent discovery and a fast-growing subject of metabolic and longevity research