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Description

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In oocytes, mitochondrial renewal does not occur through cell division because of prolonged cell cycle arrest in meiosis [138], making these cells highly dependent on mitophagy to maintain mitochondrial quality and function [139]

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As such, secondary outcomes include changes in cognition, disease severity and function before and after treatment and across the one-year study period and measures of senescence and AD biomarkers in CSF pre- and post-treatment (baseline and three months) with an optional end of study collection

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