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At first, the surface of the cartilage becomes worn, and with the continuation of the pathological process, deep cracks related to the shedding of cartilage fragments gradually forms, causing delamination and exposure of the calcified cartilage and bone below (Sandell, 2012) (Figure 1)

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PDRN and HA aren't fighting for the same spot, they do different things, at different speeds, through different mechanisms