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Tian R, Guo S, Chen S, Zhang X, Li J, Wang Y (2025) Natural products as Nrf2 modulators for ferroptosis inhibition in renal disease therapy: recent progress and future prospects

However, related research gives us some useful insights

In SURMOUNT-1, the most common adverse events at the 15 mg dose included nausea (31%), diarrhea (23%), constipation (11%), and vomiting (12%)

In terms of specific regulatory effects, the protective role of mitophagy is mainly reflected in a state of moderate activation: when cells are subjected to mild stress and mitochondria undergo local damage, mitophagy can specifically recognize and clear damaged, depolarized mitochondria, effectively reducing the abnormal release of ROS and the cytoplasmic leakage of mtDNA

The antioxidant status of an organism can be enhanced by the NRF2 activators which appear to represent a promising therapeutic approach