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Degradation of extracellular GSH, in a similar approach to degradation of extracellular cystine or cysteine 9 , is an additional potential approach

Semin Thromb Hemost 26 : 341348

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As mentioned above, NOS has significant neurotoxic impacts, and acts as a neuroprotective agent through mediation of vasodilation, plays a role in platelet aggregation inhibition, and contributes to endothelial leukocyte adhesion (Huang, 2007), and the studies above provide evidence and further support that disruptions to circadian rhythms support and increase neurotoxic effects and dampened neuroprotective aspects of NOS