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This is especially important in regions like MENA and South Africa, where fluctuating climates, urban pollution, and lifestyle factors can impact immunity

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Clinical cohort studies confirm that cerebrospinal fluid levels of lipid peroxidation markers (e.g., MDA, 8-OHdG) are significantly elevated in APOE4 carriers compared to APOE2 carriers, exhibiting a strong positive correlation with the rate of hippocampal atrophy (199)

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