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doi:10.1016/S0016-5085(98)70538-3 Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA

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In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells