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Abstract Background The alterations of the glutathione peroxidase enzyme complex system occur in physiological conditions such as aging and oxidative stress consequent to strenuous exercise

Boles published in 1997 an increased prevalence of two mitochondrial DNA polymorphisms similar to those found in migraine in patients with CVS [10] conducing them to try CVS treatment by Coenzyme Q10 (CoQ10) in association with L-carnitine and amitriptyline [11,12]

It is widely believed that CR decreases mTORC1 signaling, which would result in the activation of autophagy while reducing overall biosynthesis, decreasing protein translation as well as lipid synthesis 27

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Kim MP, Correa AM, Hofstetter W , Mehran R, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Erasmus JJ, Swisher SG