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24 Secondly, activated Akt phosphorylates forkhead box O1 (FOXO1), a transcription factor upregulating gluconeogenesis rate-limiting enzyme such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), and translocate it from nucleus to cytoplasm, which inactivate its transcriptional activity, thus inhibiting gluconeogenesis

Interestingly, from the 7th day of the experiment, the average survival values were similar, but cells treated with thiolutin exhibited a slightly faster tendency towards accelerated chronological aging

OMalley et al., 2000

How much glutathione per day is needed

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