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Functional deficiency of succinate dehydrogenase promotes tumorigenesis and development of clear cell renal cell carcinoma through weakening of ferroptosis

Key next steps are to validate the most informative sites and substrates in patient-relevant models, map lactylation across malignant, stromal and immune compartments in clinical samples, and define quantitative thresholds that can support reproducible stratification and rational combination treatment

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(2015) [137] evaluated changes in SCFAs in 140 patients diagnosed with severe systemic inflammatory response syndrome (SIRS) and compared them with healthy volunteers

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