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Plasma myeloperoxidase, an enzyme highly expressed in neutrophils and macrophages used as a marker of an inflammatory process ( Blood Lipids High levels of triglycerides and low levels of high-density lipoproteins (HDL) are risk factors for cardiovascular disease ( Free Fatty Acids Adipocyte dysfunction produces systemic inflammation, a pathogenic mechanism underlying the well-known associations between obesity, cardiovascular pathology, hypertension, and metabolic syndrome ( In cultured 3T3L1 adipocytes, nicotine-induced AMP-activated protein kinase (AMPK) phosphorylation, lipolysis, and oxidative stress in a concentration-dependent manner ( In humans, cigarette smoking and obesity have been associated with increased levels of FFAs ( In a hyperlipidemic, low-density lipoprotein receptor null mouse model, nicotine stimulated macrophages to secrete inflammatory cytokines, creating a pro-inflammatory microenvironment in the sub-endothelium that increased the aortic lesion size by 2.5 times (Figure 2

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