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Where indicated (see Results, specifically concerning the association between the GST-Pi gradient and 12-month eGFR), this was by the method of Bonferroni, accounting for 41 comparisons (biomarkers specified in advance, accounting for where markers were measured at more than one timepoint, and the associated gradient)

Signal Transduct Target Ther 9(1):124 Boutin C, Clement C, Rivoal J (2024) Post-translational modifications to cysteine residues in plant proteins and their impact on the regulation of metabolism and signal transduction

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In all KO genotypes, cFos induction in the AP and NTS was markedly blunted compared to WT mice, establishing that both AMY1R and AMY3R are necessary for transmitting cagrilintides central effects

Store reconstituted peptides in a refrigerator at 2-8C (36-46F) immediately after reconstitution