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In a study with a mouse model of PD treated with dopaminergic toxin MPTP, the administration of HDAC inhibitor phenyl butyrate significantly reduced the diminution of dopamine and loss of tyrosine hydroxylase-positive neurons in the substantia nigra (Kontopoulos et al., 2006)

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There was high intraobserver correlation with the correlation coefficients of all assessments greater than 0.986

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