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During semaglutide therapy, patients with a history of diabetic retinopathy should be closely monitored

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Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus under the brand name Mounjaro and for chronic weight management under the brand name Zepbound

Originator Merck carried it through Phase 2 trials and a Phase 2b hip-fracture study but never filed for approval, so there is no FDA-approved prescription version