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Mechanistically, this focal accumulation is thought to result from the synergistic effects of cytokines such as IL-4, IL-33, and TSLP, along with chemokines such as CCL17 and CCL22 within the inflamed tissue microenvironment (65, 66)

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Additionally, the review mentions metadoxine and lithium as potentially suitable for individuals with comorbid alcohol misuse or bipolar disorder, although further large-sample, placebo-controlled studies are needed to confirm their effectiveness

The system s real-time performance was also evaluated, achieving an average processing time of 0.3 seconds per frame